NCT00614484

Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer

Phase I/II Study of Combined Chemotherapy and High Dose, Accelerated Proton Radiation for the Treatment of Locally Advanced Non-Small Cell Lung Carcinoma

• Status: Terminated
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effectiveness of proton beam radiotherapy combined with chemotherapy for treatment of locally advanced non-small cell lung cancer.

Conditions

• Locally Advanced Non-Small Cell Lung Cancer

Interventions

Type	Name	Description
RADIATION	Proton Radiation Therapy	A five week coarse of proton radiotherapy begins on day 28 and is given once daily for the first two weeks and twice daily for the final 3 weeks. The total dose given with proton beam is 76 Gy. Weekly chemotherapy with carboplatin and taxol is given during proton therapy.
DRUG	Taxol	200 mg/m2, IV, for 2 cycles followed by 50 mg/m2 weekly for 5 weeks during radiotherapy.
DRUG	Carboplatin	AUC 6, IV, for two cycles followed by AUC 2 weekly for 5 weeks during radiotherapy.

Timeline

• Start date: 1999-08-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2008-02-13
• Last updated: 2014-05-22
• Results posted: 2014-05-22

Locations

1 site across 1 country: United States