NCT00612950

Beta-Cell Function After Near-Normalisation of Blood Glucose

Four Weeks of Near Normalisation of Blood Glucose Improves the Insulin Response to GLP-1 and GIP in Patients With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DRUG	glucagon-like peptide-1,	GLP-1:continuous infusion of ½ pmol/kg/min for a total time of 120 minutes.
DRUG	glucose dependent insulinotropic polypeptide	continuous infusion of GIP (1½ pmol/kg/min) for 120 min.
DRUG	Saline	continuous infusion of Saline for 120 min

Timeline

• Start date: 2006-10-01
• Primary completion: 2007-02-01
• Completion: 2007-05-01
• First posted: 2008-02-12
• Last updated: 2008-02-12

Locations

1 site across 1 country: Denmark