NCT00612625

Near Normalisation of BG Improves the Potentiating Effect of GLP-1

Near Normalisation of Blood Glucose Improves the Potentiating Effect of GLP-1 on Glucose Induced Insulin Secretion in Patients With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1

Conditions

• Diabetes Mellitus Type 2

Interventions

Type	Name	Description
DRUG	glucagon-like peptide-1	continuous infusion of GLP-1 (1½ pmol/kg/min)
DRUG	Saline	continuous infusion of saline

Timeline

• Start date: 2004-02-01
• Primary completion: 2004-07-01
• Completion: 2004-12-01
• First posted: 2008-02-12
• Last updated: 2008-02-12

Locations

1 site across 1 country: Denmark