NCT00611546

Perenteral Nutrition and Oxidative Stress in Preterm Infants

Study of the Oxidant-Antioxidant Effects of Parenteral Nutrition in Preterm Neonates

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 7 Days
• Healthy volunteers: Not accepted

Summary

In an effort to decrease the load of peroxides in TPN solutions, multiple studies examined different strategies such as photo-protection, adding multivitamins to the lipid emulsion rather than to the dextrose-amino acid admixture, and adding antioxidants such as glutathione to the TPN solution. However, the role of trace elements as antioxidants, and their interaction with light have not been studied. Also, the impact of TPN-related oxidants on clinical morbidities has not been addressed. Therefore, we aimed in this study of preterm infants to evaluate the role of different components of TPN on urinary peroxides and to examine the biochemical and clinical effects of light protection.

Conditions

• Preterm Infants

Interventions

Type	Name	Description
OTHER	Photo-protection	Parenteral solutions are protected from day light using aluminum covers
OTHER	Photo-exposure	Perenteral nutrition bottles and tubings are allowed to be exposed to day light.

Timeline

• Start date: 2003-04-01
• Primary completion: 2005-01-01
• Completion: 2005-01-01
• First posted: 2008-02-11
• Last updated: 2008-02-11