NCT00611117

Mechanisms of the Effect of Physical Activity on the Adaptation to a High-Fat Diet

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The study is designed to determine the effect of high physical activity level vs. low physical activity level on the adaptation to a high fat diet.

Detailed description

A high fat diet is linked to weight gain and obesity. An adjustment to the acute exposure to high fat diet is not abrupt and takes time. In a previous study from our laboratory, it has been shown that high level of physical activity can accelerate the adaptation to a high fat diet by increasing fat oxidation. In this study we will determine the mechanism involved in this adjustment. Our hypotheses are: 1. High fat diets decrease skeletal muscle glucose metabolism and decrease mitochondrial biogenesis through the upregulation of PDK4 and downregulation of PGC1α; increased physical activity will prevent these deleterious effects. 2. A high fat diet will increase hepatic and skeletal muscle lipid; increased physical activity will prevent these deleterious effects. 3. These effects are more pronounced in individuals with a low mitochondrial content

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Physical Activity Level	High vs. low physical activity during a high fat diet consumption.

Timeline

• Start date: 2007-05-01
• Primary completion: 2009-03-01
• Completion: 2020-06-01
• First posted: 2008-02-08
• Last updated: 2022-09-21

Locations

1 site across 1 country: United States