NCT00610597

Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 49 (actual)
• Sponsor: Erasme University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Detailed description

Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Conditions

• Alcoholic Liver Disease
• Chronic Hepatitis C Virus

Timeline

• Start date: 2005-01-01
• Primary completion: 2007-01-01
• Completion: 2008-01-01
• First posted: 2008-02-08
• Last updated: 2008-02-08

Locations

1 site across 1 country: Belgium