NCT00610064

Brain Effects of Sacral Neuromodulation

Brain Effects of Sacral Neuromodulation in Patients With Refractory Lower Urinary Tract Dysfunction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence, non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of central afferent activity is considered critical to this therapeutic effect but the neural mechanisms are poorly understood. We hypothesize that SNM has a significant effect on brain activity detectable by positron emission tomography (PET).

Conditions

• Urinary Tract Disease

Interventions

Type	Name	Description
RADIATION	Baseline neuroimaging	Baseline neuroimaging using PET and MRI of the brain in patients before sacral neuromodulation
RADIATION	Neuroimaging during sacral neuromodulation	Neuroimaging during sacral neuromodulation using PET

Timeline

• Start date: 2005-10-01
• Primary completion: 2009-06-01
• Completion: 2009-06-01
• First posted: 2008-02-07
• Last updated: 2010-02-05

Locations

1 site across 1 country: Switzerland