Trials / Terminated
TerminatedNCT00609154
Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates
- Status
- Terminated
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- Albert Einstein College of Medicine · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
The gut hormone glucagon like peptide-1 (GLP-1) has been shown to have important effects on maintaining the function and health of the insulin producing beta cells. This hormone is known to increase the production rate of new insulin as well as increase the release of insulin into the blood.
Detailed description
We will measure the rate of new insulin production in subjects with Type 2 diabetes compared to non diabetic subjects. We hypothesize that subjects with Type 2 diabetes make less insulin in response to GLP-1 compared to non diabetic subjects.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | glucagon like peptide-1 | GLP-1 1 pmole/kg/min |
| DIETARY_SUPPLEMENT | glucose control | glucose without GLP-1 |
Timeline
- Start date
- 2010-08-12
- Primary completion
- 2014-05-13
- Completion
- 2014-05-13
- First posted
- 2008-02-06
- Last updated
- 2024-02-28
- Results posted
- 2024-02-28
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00609154. Inclusion in this directory is not an endorsement.