NCT00608348

Sympathetic Nerve Activity During Hypoglycemia and Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity.

Detailed description

The body has defensive responses to correct low blood sugar (hypoglycemia). A vital component of this response is release of glucagon and activation of the sympathetic nervous system, which provides the means for raising blood glucose levels towards normal. We can measure circulating hormones indicating the level of these responses, but additionally, sympathetic nervous system responses can be measured directly. We can measure the sympathetic nerve activity that controls blood flow to muscles (MSNA) and blood flow and sweating to skin (SSNA). The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity. We would also like to determine what the sympathetic response is to cycling exercise with insulin and normal blood sugar. Therefore, we would like to test the sympathetic responses to insulin with normal blood glucose, hypoglycemia, and during exercise bouts and normal blood glucose, with or without insulin.

Conditions

• Diabetes Mellitus

Interventions

Type	Name	Description
PROCEDURE	Hyperinsulinemic glucose clamp procedures	2 hours of either euglycemic or hypoglycemic glucose clamping
PROCEDURE	moderate exercise	90 minutes of moderate exercise with either hyperinsulinemia or euinsulinemia

Timeline

• Start date: 2002-04-01
• Primary completion: 2008-07-01
• Completion: 2008-07-01
• First posted: 2008-02-06
• Last updated: 2015-06-10

Locations

1 site across 1 country: United States