NCT00608101

Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus

Hypoglycemia Associated Autonomic Failure in Type 1 DM, Question 1

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine what corticosteroid receptor (and the dose of) is responsible for cortisol inducing hypoglycemia associated autonomic dysfunction in Type 1 DM. Specifically, we aim to determine whether stimulating the type 1 corticosteroid receptor (via fludrocortisone), the type 2 corticosteroid receptor (via dexamethasone), or both causes hypoglycemia associated autonomic dysfunction in Type 1 DM.

Conditions

• Type 1 Diabetes

Interventions

Type	Name	Description
DRUG	Fludrocortisone	Oral Fludrocortisone 0.2 mg x 2 prior to each experimental period on Day 1
DRUG	Dexamethasone	Oral Dexamethasone 0.75 mg x 2 administered prior to each experimental period on Day 1

Timeline

• Start date: 2010-09-01
• Primary completion: 2010-09-01
• Completion: 2010-09-01
• First posted: 2008-02-06
• Last updated: 2014-12-11