NCT00606827

Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy

Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy in Patients Undergoing Coronary Angiography

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 500 (actual)
• Sponsor: Ospedale Misericordia e Dolce · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.

Conditions

• Contrast-Induced Nephropathy

Interventions

Type	Name	Description
DRUG	Sodium Bicarbonate	Patients in the sodium bicarbonate group (154 mEq/L) received 3 ml/kg for 1 hour before contrast medium, followed by an infusion of 1 ml/kg/h for 6 hours after the procedure
DRUG	Isotonic Saline	Patients assigned to the isotonic saline group received 1 ml/kg/h 0.9% sodium chloride for 12 hours before and after the procedure

Timeline

• Start date: 2005-01-01
• Completion: 2006-03-01
• First posted: 2008-02-05
• Last updated: 2012-05-08

Locations

1 site across 1 country: Italy