NCT00605202

Effect of Licorice and Hydrochlorothiazide on Plasma Potassium

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Oulu · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This clinical trial is designed to study the effect of the combination of licorice and hydrochlorothiazide on plasma potassium levels in volunteers. In one arm, 10 healthy volunteers will be given 32 grams of licorice a day together with a 25 mg dose of daily hydrochlorothiazide for 14 days. This combination is compared with 32 grams of licorice a day for 14 days given in the other arm. The study is a randomized, open-label cross-over trial. There is at least a 3-week wash-out between the arms. The hypothesis is that the combination of licorice and hydrochlorothiazide will cause hypokalemia. The main outcome measure is the change in the plasma level of potassium between the arms.

Conditions

• Hypokalemia

Interventions

Type	Name	Description
DRUG	Hydrochlorothiazide	Hydrochlorothiazide 25 mg a day for 14 days.
DIETARY_SUPPLEMENT	Licorice	Licorice candy 32 grams a day for 14 days.

Timeline

• Start date: 2008-02-01
• Primary completion: 2009-01-01
• Completion: 2009-01-01
• First posted: 2008-01-30
• Last updated: 2009-12-15
• Results posted: 2009-12-09

Locations

1 site across 1 country: Finland