NCT00603330

Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function

Infusion of Mesenchymal Stem Cells as Treatment for Steroid-Resistant Grade II to IV Acute GVHD or Poor Graft Function: a Multicenter Phase II Study

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Liege · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The present project aims at investigating the role of MSC for the treatment of patients with Part 1: Steroid-refractory grade II-IV acute GVHD. Part 2: Poor graft function (PGF) Part 3: Low or falling donor T-cell chimerism after allogeneic HCT. This is a multicenter phase II study examining the feasibility and efficacy of this approach.

Detailed description

Part 1: complete recruitment Part 2: complete recruitment Part 3: recruiting

Conditions

• Graft-versus-host Disease
• Poor Graft Function
• Low Donor T-cell Chimerism

Interventions

Type	Name	Description
BIOLOGICAL	Mesenchymal stem cells	Mesenchymal Stem Cell infusion

Timeline

• Start date: 2008-01-01
• Primary completion: 2024-08-01
• Completion: 2024-08-01
• First posted: 2008-01-29
• Last updated: 2024-05-09

Locations

12 sites across 2 countries: Belgium, Netherlands