NCT00597688

Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia

Oral Mucosal Decontamination With Chlorhexidine for Prevention of Ventilator Associated Pneumonia in Children - A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 86 (actual)
• Sponsor: All India Institute of Medical Sciences · Academic / Other
• Sex: All
• Age: 3 Months – 15 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if oral mucosal application of chlorhexidine gel will prevent the development of ventilator associated pneumonia in children.

Detailed description

Ventilator associated pneumonia as the name suggests refers to pneumonia occurring in the setting of mechanical ventilation. It accounts of 86% of nosocomial pneumonia and in contrast to other more common nosocomial infections is accompanied by a mortality rate of upto 76% in certain settings. A number of preventive methods have been studied to reduce the rate of VAP but a consensus is lacking with regards to appropriate preventive strategies. Studies in adults have shown a beneficial effect of oral mucosal application of chlorhexidine but similar studies in pediatric population are not available. This research project aims at addressing the gap.

Conditions

• Ventilator Associated Pneumonia

Interventions

Type	Name	Description
DRUG	Chlorhexidine gel	Oral mucosal application of chlorhexidine gel
DRUG	Placebo gel	Oral mucosal application of placebo gel

Timeline

• Start date: 2007-11-01
• Primary completion: 2009-04-01
• Completion: 2009-04-01
• First posted: 2008-01-18
• Last updated: 2011-03-23

Locations

1 site across 1 country: India