NCT00593671

Preimplantation Genetic Screening in Women Over 35 Year

Preimplantation Genetic Screening for Aneuploidy in Embryos After in Vitro Fertilization in Women Over 35: a Prospective Controlled Randomized Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 35 Years – 45 Years
• Healthy volunteers: Accepted

Summary

In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS. In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.

Conditions

• In Vitro Fertilization

Interventions

Type	Name	Description
PROCEDURE	Preimplantation genetic screening after embryo biopsy	Preimplantation genetic screening after embryo biopsy

Timeline

• Start date: 2002-06-01
• Primary completion: 2007-01-01
• Completion: 2007-01-01
• First posted: 2008-01-15
• Last updated: 2008-01-15

Locations

1 site across 1 country: Belgium