NCT00592566

Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis

An Open Randomized Controlled Trial of Desmopressin, and Dexamethasone as Adjunctive Therapy in Patients With Pulmonary Hemorrhage Associated With Leptospirosis

• Status: Terminated
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 15 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Background: Pulmonary involvement in leptospirosis has been reported to be on the increase and is emerging as the main cause of death due to leptospirosis in many countries, including Thailand. Methods: A prospective randomized controlled trial of desmopressin or high dose dexamethasone as adjunctive therapy in patients with suspected pulmonary hemorrhage associated with leptospirosis was conducted between July 2003 and October 2006 at 5 hospitals in Thailand.

Conditions

• Leptospirosis

Interventions

Type	Name	Description
DRUG	Dexamethasone, desmopressin	200 mg of dexamethasone IV infusion OD for 3 days or 0.3 microgram/ kg of desmopressin in 50 ml of saline, as a 30- minute infusion

Timeline

• Start date: 2003-07-01
• Primary completion: 2006-10-01
• Completion: 2006-10-01
• First posted: 2008-01-14
• Last updated: 2008-01-14

Locations

1 site across 1 country: Thailand