NCT00592397

Prestudy: Lifestyle and Cardiovascular Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: Male
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this pilot study is to optimize conditions for a planned human intervention study focusing on how diet predispose for, and influence, lifestyle disease development and its consequence in cardiovascular disease development.

Detailed description

Common for many of the risk factors of lifestyle diseases is that they are induced by improper diet. Recent research has shown that especially total amount and composition of the macro nutrients, protein, carbohydrate and fats, is important. A time course experiment has been performed where 5 subjects underwent a diet intervention for four weeks with a controlled, balanced macro nutrient energy content of every meal. The sampling time points were 0, 1, 2, 7, 14 and 28 days. The goals were to determine optimal length of intervention with stabilization of gene expression to occur and compare blood and subcutaneous abdominal fat tissue as source of biological material for RNA for DNA microarray analysis. Microarray analysis were performed on 3 of the 5 subjects.

Conditions

• Obesity
• Diabetes Mellitus
• Cardiovascular Diseases

Interventions

Type	Name	Description
OTHER	Balanced macronutrient diet intervention	Isocaloric dietary changes from typically Western diet to balanced macronutrient composition.

Timeline

• Start date: 2006-03-01
• Primary completion: 2006-04-01
• Completion: 2006-04-01
• First posted: 2008-01-14
• Last updated: 2017-01-30

Locations

1 site across 1 country: Norway