NCT00591162

Bone Disease in Severely Burned Children

• Status: Terminated
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 254 (actual)
• Sponsor: The University of Texas Medical Branch, Galveston · Academic / Other
• Sex: All
• Age: 5 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

Bone metabolism is adversely affected by severe burns in children for a period of time.

Detailed description

More closely monitored biochemical and radiologic parameters of bone and mineral metabolism will increase the likelihood of earlier detection of abnormalities and possible therapeutic interventions.

Conditions

• Burn

Interventions

Type	Name	Description
DRUG	Tetracycline	Two courses of IV Tetracycline(10mg./kg./day for two days)separated by a two week interval.
RADIATION	Duel Energy X-Ray Absorptiometry (DEXA)	DEXA before discharge from acute admission and again one year post burn.
PROCEDURE	Bone Biopsy	Bone biopsy to be taken in the operation room at the last skin grafting operation at the site of the iliac crest. A second bone biopsy will be taken one year later post discharge from the acute admission.

Timeline

• Start date: 1992-10-01
• Primary completion: 2008-06-01
• Completion: 2008-06-01
• First posted: 2008-01-11
• Last updated: 2014-06-06

Locations

1 site across 1 country: United States