NCT00590928

Gastric pH in Critically Ill Patients

Effect of Intravenous Esomeprazole Versus Ranitidine on Gastric pH in Critically Ill Patients - a Prospective, Randomized, Double-Blind Study.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

H2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. Various studies demonstrated superiority of proton pump inhibitors over H2-receptor antagonists in increasing gastric pH and in healing gastric acid-dependent diseases. It is unknown, whether proton pump inhibitors are more effective in increasing gastric pH than H2-receptor antagonists in critically ill patients requiring stress ulcer prophylaxis.

Detailed description

Gastric pH is measured continuously for 72 hours with a pipolar microelectrode placed between 7 and 15cm below the lower esophageal sphincter.

Conditions

• Critically Ill Patients
• Indication for Stress Ulcer Prophylaxis

Interventions

Type	Name	Description
DRUG	esomeprazole	40mg once daily
DRUG	ranitidine	50mg every h hours

Timeline

• Start date: 2004-07-01
• Primary completion: 2006-06-01
• Completion: 2006-06-01
• First posted: 2008-01-11
• Last updated: 2008-01-11

Locations

1 site across 1 country: Austria