NCT00588796

Study of Fibrinogen Metabolism During Severe Trauma and Burns

Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: United States Army Institute of Surgical Research · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.

Detailed description

In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive.

Conditions

• Burn Injury
• Major Trauma

Timeline

• Start date: 2005-02-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2008-01-09
• Last updated: 2015-02-04