NCT00584168

Using Dexamethasone After Uvulopalatopharyngoplasty

Decreasing Morbidity After Uvulopalatopharyngoplasty With the Use of Dexamethasone - A Randomized Double Blinded Placebo Controlled Trial

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study looks at lessening the pain after a Uvulopalatopharyngoplasty (UPPP) surgery by using Dexamethasone (a corticosteroid).

Detailed description

The study was designed because patients have a lot of pain after they have a UPPP. Certain drugs called steroids may lessen the pain associated from this surgery. This study uses Dexamethasone (a corticosteroid), to see if it will help reduce pain, decrease the amount of time until the patient can begin to eat or return to normal activity, or increase their satisfaction with pain management. In this study the patients will be randomized (computer chosen) to receive either the study drug (dexamethasone), or a placebo. The patient will start the day before surgery with a single pill. They will then receive the dexamethasone or a placebo twice daily for the next four days and then once daily for the next two days for a total of seven days. Afterward, they will be asked to complete a questionnaire. The five questions ask patients to access the amount of pain they have, how much of their normal diet or activity they have returned to, and how much pain medication they have taken. At the next follow-up visit they will be asked to complete another questionaire (9 questions) about the patient's satisfaction with pain management.

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Dexamethasone	They will take a pill the day before surgery, twice daily for the next four days and then once daily for the next two days for a total of seven days.
DRUG	Placebo	They will take a pill the day before surgery, twice daily for the next four days and then once daily for the next two days for a total of seven days.

Timeline

• Start date: 2005-03-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2008-01-02
• Last updated: 2012-02-02

Locations

2 sites across 1 country: United States