NCT00583687

Pulse Contour Analysis and Tissue Oxymetry in Changing Vascular Tone

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare changes of minimally invasive arterial pulse contour cardiac output with changes of intermittent and continuous thermodilution cardiac output by pulmonary artery catheter in hemodynamic unstable patients with rapid changing vascular tone (changing dosage of vasoactive drugs or inotropics, or volume challenge). Simultaneously, global parameters of oxygen delivery and consumption will be compared with regional flow parameters and tissue oxymetry (near infrared spectrometry and laser-Doppler). While continuous thermodilution cardiac output is used for patient management, pulse contour cardiac output, intermittent thermodilution cardiac output and tissue oxymetry is only used for monitoring.

Conditions

• Cardiac Output, High
• Cardiac Output, Low
• Vasodilation
• Vasoconstriction
• Hemodynamics

Interventions

Type	Name	Description
DEVICE	Vigileo TM / Flotrac TM (Minimally invasive cardiac output system consisting of arterial line sensor and cardiac output monitor)	Attachment of the arterial line sensor and pulse contour cardiac output monitor to the arterial line of the patient.
OTHER	Passive leg raising	Passive leg raising for prediction of fluid responsiveness with arterial pulse contour analysis.
OTHER	Volume challenge / Change of vasoactive drugs or inotropics	Either a volume challenge (using colloids or crystalloids) or a change in the dosage of of vasoactive drugs or inotropics, or a combination of them, as proposed by the treating physician.
DEVICE	Inspectra TM/O-To-See TM (Tissue oxymetry with near infrared spectroscopy and laser-Doppler)	Tissue oxymetry continuously measured with near infrared spectrometry and laser Doppler during the whole study period.

Timeline

• Start date: 2007-12-01
• Primary completion: 2009-01-01
• Completion: 2009-01-01
• First posted: 2007-12-31
• Last updated: 2009-04-28

Locations

1 site across 1 country: Switzerland