NCT00581633

Acute Salt Handling in Orthostatic Intolerance

Acute Renal Salt Handling in Orthostatic Intolerance

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.

Detailed description

Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt \& water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.

Conditions

• Postural Tachycardia Syndrome
• Orthostatic Tachycardia
• Orthostatic Intolerance

Interventions

Type	Name	Description
OTHER	normal saline (0.9%)	liter normal saline over 30 minutes x 1 dose

Timeline

• Start date: 2007-02-01
• Primary completion: 2029-12-01
• Completion: 2029-12-01
• First posted: 2007-12-27
• Last updated: 2025-10-06

Locations

1 site across 1 country: United States