NCT00581048

Study on the Role of Treatment With Vitamin E on Asthmatic Responses in Allergic Asthmatics

Oxidant Stress and Allergic Asthma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Asthma is a common respiratory disease of unknown etiology which currently affects approximately 7.5 % of the adult population ( ). Asthma is an inflammatory disorder of the airways. Airway inflammation is evident not only in patients with fatal asthma but also in mild asthmatics ( ). Oxidant stress, defined as inadequately controlled generation of toxic reactive oxygen species (ROS) in the cells or tissues is a common feature of inflammation, and has also been documented in asthma ( , ). However, the current understanding of the relationship between the inflammation and the oxidant stress in asthmatic airways is poor. Does oxidant stress contribute to the expression of asthmatic phenotypes independently of inflammation? If so, could asthmatics benefit from supplementation of antioxidants? These questions have been nagging us since our laboratory provided credible evidence of oxidant injury in the airways of allergic asthmatics ( ). The purpose of our study is to more precisely determine 1/ the pathophysiologic role of oxidative stress, and 2/ usefulness of antioxidant therapy using vitamin E in allergic asthma.

Conditions

• Allergic Asthma

Interventions

Type	Name	Description
DRUG	Natural source d-α-tocopheryl acetate	1500 units daily for 16 weeks

Timeline

• Start date: 2006-12-01
• Primary completion: 2011-04-01
• Completion: 2011-10-01
• First posted: 2007-12-27
• Last updated: 2018-03-29
• Results posted: 2018-02-06

Locations

1 site across 1 country: United States