NCT00580996

Water and the Gastropressor Response - Tachyphylaxis

Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Satish R. Raj · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

Detailed description

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

Conditions

• Orthostatic Hypotension

Interventions

Type	Name	Description
OTHER	water high dose	water 16 oz PO x 1
OTHER	water tiny dose	water 1 oz PO x 1

Timeline

• Start date: 2006-07-01
• Primary completion: 2029-12-01
• Completion: 2029-12-01
• First posted: 2007-12-27
• Last updated: 2025-10-10

Locations

1 site across 1 country: United States