NCT00577057

Benefit of Changing Chemoradiotherapy Sequence and Modifying Radiotherapy Schedule for Advanced Nasopharyngeal Cancer

Randomized Trial to Evaluate the Therapeutic Gain by Changing the Chemoradiotherapy From Concurrent-adjuvant to Induction-concurrent Sequence, and the Radiotherapy From Conventional to Accelerated Fractionation for Advanced Nasopharyngeal Carcinoma

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 798 (estimated)
• Sponsor: Hospital Authority, Hong Kong · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: —

Summary

The objectives of this clinical study are threefold: 1. To compare the benefits in cancer control and survival obtained from adding induction-concurrent chemotherapy to radiation with those from adding concurrent-adjuvant chemotherapy to radiation. 2. To test whether replacing fluorouracil with Xeloda in combining with cisplatin (PF or PX, respectively) in the chemotherapy plan will maintain or improve further the chemotherapy benefits while reducing the duration of hospital stay. 3. To see if accelerated fractionation radiotherapy can improve the outcome of patients as compared with conventional fractionation radiotherapy.

Conditions

• Nasopharyngeal Neoplasms

Interventions

Type	Name	Description
PROCEDURE	Conventional Radiotherapy
PROCEDURE	Accelerated Radiotherapy
DRUG	Cisplatin
DRUG	5-fluorouracil
DRUG	Capecitabine

Timeline

• Start date: 2006-09-01
• Completion: 2013-08-01
• First posted: 2007-12-19
• Last updated: 2013-08-22

Locations

6 sites across 1 country: China