NCT00576394

Aggressive Versus Moderate Glycemic Control in Diabetic Coronary Bypass Patients

Impact of Aggressive Versus Moderate Glycemic Control on Clinical Outcomes Following Coronary Artery Bypass Graft Surgery in Diabetic Patients

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: American Heart Association · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control (120-180mg/dl) will further improve outcomes.

Detailed description

150 diabetic patients will be randomized to achieve aggressive glycemic control (80-120mg/dl) vs moderate control (120-180mg/dl) using intravenous insulin infusions beginning at anesthetic induction and continuing for 18 hours following surgery.

Conditions

• Glycemic Control

Interventions

Type	Name	Description
DRUG	IV Insulin drip	IV insulin drip at 100units insulin in 100ml saline designed to keep blood glucose between 120-180mg/dl
DRUG	Insulin	IV insulin drip to keep serum glucose between 80-120mg/dl.

Timeline

• Start date: 2006-10-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2007-12-19
• Last updated: 2015-06-23

Locations

1 site across 1 country: United States