NCT00574678

Analyzing the Composition of Tears to Identify Cancer

ACT: Analyzing the Composition of Tears to Identify Cancer (Breast, Ovarian, Colon)

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: University of Arkansas · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will further evaluate the use of protein identification or protein pattern (signature) found in tears. We hypothesize that differences exist between the protein profile in tear fluid from patients with versus without cancer.

Detailed description

Specifically, this study will compare the protein profile in tear fluid from patients with breast, ovarian or colon cancer versus "normal male and female patients" for differences that show promise as a diagnostic indicator. If such differences can be found, then their diagnostic potential will be assessed and developed further in a subsequent study. The long-term goal of this project will be to develop a screening tool for the detection of breast and/or other cancers.

Conditions

• Breast Cancer
• Ovarian Cancer
• Colon Cancer
• Benign Disease

Interventions

Type	Name	Description
OTHER	Tear collection	A tear sample (\~75 microliters in a tuberculin syringe with the needle removed) will be taken at time of the initial clinic visit. After collection, the tears will be put directly on ice and taken to the lab. If it is not possible to obtain natural tears, an "eye wash" method using sterile saline will be employed and the fluid collected using the aforementioned technique. The SELDI-MS process will be conducted on the specimen immediately. The remainder of the tear specimen will be stored in a -80ºC freezer until completely analyzed.

Timeline

• Start date: 2006-12-01
• Primary completion: 2016-02-01
• Completion: 2016-02-01
• First posted: 2007-12-17
• Last updated: 2021-08-05

Locations

1 site across 1 country: United States