NCT00574119

Effect of Aldosterone on Energy Starvation in Heart Failure

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

We plan to study the concept of "energy starvation" in heart failure by evaluation of patients with nonischemic dilated cardiomyopathy (NIDCM) (heart failure with reduced heart pump function due to causes other than heart attack). We will use a combination of positron emission tomography and magnetic resonance imaging to study metabolism, anatomy, function, blood flow and efficiency, before and after 6 months' treatment with the drug spironolactone which blocks the deleterious effects of the hormone aldosterone on the myocardium (heart muscle).

Detailed description

Preliminary results showed reduced subendocardial myocardial perfusion reserve in NIDCM compared to normal subjects, and that the degree of impaired perfusion reserve was related to the oxidative metabolic rate as measured by positron emission tomography.

Conditions

• Heart Failure
• Nonischemic Dilated Cardiomyopathy

Interventions

Type	Name	Description
DRUG	spironolactone	spironolactone 50 mg daily for 6 months

Timeline

• Start date: 2007-12-01
• Primary completion: 2012-07-01
• Completion: 2012-07-01
• First posted: 2007-12-17
• Last updated: 2019-06-18
• Results posted: 2019-06-18

Locations

1 site across 1 country: United States