NCT00573924

Trial of Oral Versus Intravenous Proton Pump Inhibitor on Intragastric pH in Patients With Bleeding Ulcers

Prospective Randomized Comparison of the Effect of Frequent Oral Dosing Versus Constant IV Infusion of Proton Pump Inhibitor on Intragastric pH in Patients With Bleeding Ulcers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with bleeding ulcers identified by endoscopy will be randomly assigned to receive an acid-blocking drug (called a proton pump inhibitor \[PPI\]) either by mouth every 3 hours for 24 hours or intravenously (IV) by constant infusion for 24 hours. A pH probe in the stomach will be used to determine intragastric pH (a measure of the acid production in the stomach) at baseline and during the 24 hours of therapy. The purpose of the study is to determine if the continuous intravenous administration of the drug provides better reduction of acid in the stomach than the oral administration.

Conditions

• Peptic Ulcer Hemorrhage

Interventions

Type	Name	Description
DRUG	Proton pump inhibitor (lansoprazole)	1. 120 mg PO and then 30 mg PO q 3 h from 3 to 21 hrs 2. 90 mg IV bolus followed 9 mg/hr infusion for 24 hrs

Timeline

• Start date: 2006-02-01
• Completion: 2007-12-01
• First posted: 2007-12-14
• Last updated: 2011-02-08

Locations

1 site across 1 country: United States