NCT00568711

Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 476 (actual)
• Sponsor: Dong-Min Kim · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others. In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.

Conditions

• Scrub Typhus

Interventions

Type	Name	Description
DRUG	doxycycline	a 5-day course of 100 mg bid doses of doxycycline
DRUG	rifampin	a 5-day course of daily 600-mg doses of rifampin

Timeline

• Start date: 2006-09-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2007-12-06
• Last updated: 2019-02-08

Locations

1 site across 1 country: South Korea