NCT00565149

PROOF: PROtein OverFeeding Effect on Body Weight

Dietary Protein Content Determines Weight Gain During High Fat Overfeeding

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study is designed to determine the effects of dietary protein content on overfeeding.

Detailed description

When body weight increases, the expenditure of energy increases as a mechanism to dissipate the excess calories. The role of diet composition in over-feeding/energy dissipation in humans is unknown. We propose that: 1. High and low protein diet will result in less weight gain as compared to a moderate protein diet during a 56d high fat overfeeding. 2. Increase in energy expenditure and spontaneous physical activity, adjusted for lean and fat mass will be greater in the high and low protein diets as compared to a moderate protein diet. 3. the average size of the fat cells and the pattern of genes expressed in the adipose tissue, skeletal muscle, and peripheral blood mononuclear cells will "predict" which group of subjects will gain the most weight (and fat mass) independent of the level of the protein in the diet.

Conditions

• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	PROOF	dietary overfeeding with high, low or normal protein content

Timeline

• Start date: 2005-03-01
• Primary completion: 2008-03-01
• Completion: 2016-03-01
• First posted: 2007-11-29
• Last updated: 2021-08-25

Locations

1 site across 1 country: United States