NCT00564031

Hormonal Replacement Therapy and Small Artery Function

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Karolinska University Hospital · Academic / Other
• Sex: Female
• Age: 50 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Endothelial dysfunction in resistance arteries in women after the menopause is important for the development of high blood pressure and cardiovascular disease

Detailed description

We aim to study the effects of different hormone replacement therapies (HRT) on the function and morphology of resistance arteries, and to look for their mechanistic basis. We expect that HRT with estrogens or in combination with MPA may benefit the function of resistance arteries and may preserve the morphological integrity of endothelial cells by regulatory actions on the cytoskeleton.

Conditions

• Menopause

Interventions

Type	Name	Description
DRUG	Femanest	2mg/day
DRUG	gestapuran	5mg/day
DRUG	placebo	daily
DRUG	Femanest plus Gestapuran	combined daily

Timeline

• Start date: 2003-01-01
• Completion: 2004-08-01
• First posted: 2007-11-27
• Last updated: 2007-11-27

Locations

1 site across 1 country: Sweden