NCT00559806

The Effect of Aging and Immobilisation on Muscle

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: Male
• Age: 20 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	2 weeks of unilateral immobilisation and 4 weeks of resistance training	2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
OTHER	2 weeks of unilateral immobilisation and 4 weeks of resistance training	2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Timeline

• Start date: 2007-01-01
• Completion: 2007-05-01
• First posted: 2007-11-16
• Last updated: 2007-11-16

Locations

1 site across 1 country: Denmark