NCT00555776

Effect of Gabapentin on Idiopathic Subjective Tinnitus

Phase 2 Effect of Gabapentin on Idiopathic Subjective Tinnitus

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Islamic Azad University of Mashhad · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine wether Gabapentin which is useful for treating neuropathic pains, is effective on idiopathic subjective tinnitus.

Detailed description

Tinnitus is the perception of sound in the absence of acoustic stimulation. It can be subjective or objective. . Despite numerous researches,no effective treatment for people who suffer from tinnitus has yet been stablished. As there are many evidences suggesting that loss of inhibition in the central nervous system may be responsible for many aspects of auditory dysfunction,including tinnitus; and as Gabapentin (Neurontin), a gama-aminobutyric acid (GABA) analogue, is an effective medication in conditions where inhibition in the CNS is impaired; we guess that Gabapentin might be useful for treating idiopathic subjective tinnitus.

Conditions

• Subjective Tinnitus

Interventions

Type	Name	Description
DRUG	Gabapentin	Gabapentin, 600 mg bid for the first two weeks, increased to a maximum dose of 1800 mg per day during the next 6 weeks if necessary.
DRUG	placebo	placebo is given with the same definition as Gabapentin

Timeline

• Start date: 2007-01-01
• Primary completion: 2008-04-01
• Completion: 2008-10-01
• First posted: 2007-11-09
• Last updated: 2009-01-06

Locations

1 site across 1 country: Iran