NCT00553072

Magnesium Sulphate in Perinatal Asphyxia

Magnesium Sulphate in Perinatal Asphyxia: A Randomized Placebo Controlled Trial.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Sheri Kashmir Institute of Medical Sciences · Academic / Other
• Sex: All
• Age: 1 Hour – 6 Hours
• Healthy volunteers: Not accepted

Summary

Magnesium sulphate has been shown to be neuroprotective. The investigators hypothesize that magnesium sulphate infusion given to babies with perinatal asphyxia should improve outcome in the immediate neonatal period.

Detailed description

Magnesium sulphate has a neuroprotective potential as has been shown by many studied in pregnant ladies with eclampsia where it helped neonates also and in mothers with preterm labour where the incidence of cerebral palsy was less. We designed a randomised controlled trial on 40 neonates with severe perinatal asphyxia to see whether it helps in the short term outcome of these neonates.

Conditions

• Perinatal Asphyxia , Moderate to Severe HIE

Interventions

Type	Name	Description
DRUG	Magnesium sulphate	250 mg/kg/dose in 1 ml normal saline
DRUG	Normal saline	1 ml/kg/dose

Timeline

• Start date: 2004-09-01
• Primary completion: 2006-08-01
• Completion: 2006-08-01
• First posted: 2007-11-05
• Last updated: 2016-10-14

Locations

1 site across 1 country: India