Trials / Completed
CompletedNCT00552097
Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)
Effect of Combination Ezetimibe and High-Dose Simvastatin vs Simvastatin Alone on the Atherosclerotic Process in Subjects With Heterozygous Familial Hypercholesterolemia (The ENHANCE Trial)
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 720 (actual)
- Sponsor
- Organon and Co · Industry
- Sex
- All
- Age
- 30 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of the study is to determine whether ezetimibe plus simvastatin will be more effective than simvastatin alone in preventing progression of atherosclerosis of the inner layer of the carotid artery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | ezetimibe (plus simvastatin) | oral tablets; ezetimibe 10 mg (plus simvastatin 80 mg) once daily for 24 months |
| DRUG | placebo (plus simvastatin) | tablets; placebo to match ezetimibe 10 mg (plus simvastatin 80 mg) once daily for 24 months |
Timeline
- Start date
- 2002-06-01
- Primary completion
- 2006-04-25
- Completion
- 2006-04-25
- First posted
- 2007-11-01
- Last updated
- 2024-08-15
Source: ClinicalTrials.gov record NCT00552097. Inclusion in this directory is not an endorsement.