NCT00551434

Effect of Creatine and L-Arginine on Endothelial Function

Effect of Creatine and L-Arginine on Endothelial Function in Patients With Coronary Artery Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 119 (actual)
• Sponsor: Boston University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creatine	Creatine 21 g daily
DIETARY_SUPPLEMENT	L-arginine and creatine	L-arginine
DIETARY_SUPPLEMENT	l-arginine	l-arginine 9 g daily
DIETARY_SUPPLEMENT	placebo, double	placebo

Timeline

• Start date: 2002-08-01
• Completion: 2005-12-01
• First posted: 2007-10-31
• Last updated: 2007-10-31