NCT00547885

Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-malignant Pain

Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-Malignant Pain

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

We wish to compare the effect of long acting vs short acting opioids in chronic non-malignant pain. The study opioid is Dihydrocodeine Continus and Dihydrocodeine 30 mg tablets. We measure pain relief, health related quality of life, sleep, breakthrough pain and depression with validated questionnaires to compare the two treatment arms. Hypothesis: The pain relief will be better and more stable with long acting opioids. Quality of sleep, breakthrough pain and quality of life will also be improved with long acting dihydrocodeine.

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Dihydrocodeine	Group 1: 2\* 60 mg dihydrocodeine long acting + up to four placebo short action Group 2: 3\* 60 mg dihydrocodeine long acting + up to six placebo short action Group 3: 4\* 60 mg dihydrocodeine long acting + up to eight placebo short action Group 4: 2 placebo for long acting + up to 4\*30 mg dihydrocodeine short acting Group 5: 3 placebo for long acting + up to 6\*30 mg dihydrocodeine short acting Group 6: 3 placebo for long acting + up to 8\*30 mg dihydrocodeine short acting

Timeline

• Start date: 2007-10-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2007-10-23
• Last updated: 2014-12-31

Locations

1 site across 1 country: Norway