NCT00546741

Drug Interaction With Metformin

Pharmacokinetic Drug Interaction Study With Dapagliflozin and Metformin in Healthy Subjects

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: AstraZeneca · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to determine the effect of metformin on dapagliflozin exposure and the effect of dapagliflozin on metformin exposure in healthy volunteers. Additionally, the safety and tolerability of dapagliflozin will be assessed in the presence and absence of metformin in healthy volunteers

Conditions

• Healthy Male and Female Subjects

Interventions

Type	Name	Description
DRUG	Dapagliflozin	Tablets, Oral, 20 mg, once daily single dose
DRUG	Metformin	Tablets, Oral, 1000 mg, once daily, single dose
DRUG	Dapagliflozin + Metformin	Tablets, Oral, once daily, single dose Dapagliflozin: 20 mg Metformin: 1000 mg

Timeline

• Start date: 2007-11-01
• Primary completion: 2008-02-01
• Completion: 2008-02-01
• First posted: 2007-10-19
• Last updated: 2016-12-20

Locations

1 site across 1 country: United States