NCT00542126

Luteal-Phase GnRH Agonist Administration in Frozen-Thawed IVF Embryo Transfer Cycles

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: —
• Sponsor: Shaare Zedek Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years – 38 Years
• Healthy volunteers: Not accepted

Summary

Supraphysiological hormonal stimulation enables collecting many oocytes in an In-Vitro Fertilization treatment, but may have a negative effect on uterine function and contribute the fact that the majority of preembryos placed in the uterus fail to implant. Several medical agents were shown to be beneficial when given in the luteal phase of an IVF cycle, but the optimal regimen has not been yet determined. In 2006, a European group reported that addition of GnRH analog (Decapeptyl) as luteal support in IVF cycle significantly improved pregnancy and delivery rates. It is not known whether this positive effect influences the corpus luteum, embryo or the uterus. The researchers sought to evaluate the effect of GnRH administration as luteal support in frozen-thaws IVF cycle.

Conditions

• Pregnancy Rate

Interventions

Type	Name	Description
DRUG	Decapeptyl 0.1 mg after embryo transfer	Decapeptyl 0.1 mg (Ferring, Kiel, Germany) 3 days following embryo transfer

Timeline

• Start date: 2007-12-01
• Completion: 2009-09-01
• First posted: 2007-10-10
• Last updated: 2007-10-10

Locations

1 site across 1 country: Israel