NCT00539799

Steroids in the Maintenance of Remission of Proliferative Lupus Nephritis

Corticosteroids in the Maintenance Therapy of Proliferative Lupus Nephritis: a Randomized Pilot Study

• Status: Withdrawn
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Cambridge University Hospitals NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

There is debate as to whether long-term low-dose steroids such as prednisolone help to suppress relapses of systemic lupus erythematosus (SLE) in patients who are in remission from their lupus nephritis. If low-dose prednisolone reduces relapses, these beneficial effects may be counter-balanced by the long-term side-effects associated with prednisolone. This pilot study will determine the feasibility of conducting a larger randomized control trial that will answer the question of whether or not long-term low-dose prednisolone (5 - 7.5 mg/day) reduces the flares of SLE in patients with previous lupus nephritis.

Conditions

• Lupus Nephritis

Interventions

Type	Name	Description
DRUG	prednisolone	5 - 7.5 mg/day
DRUG	Placebo	Matched placebo to prednisolone

Timeline

• First posted: 2007-10-05
• Last updated: 2008-05-29

Locations

1 site across 1 country: United Kingdom