NCT00538707

Effect of Mental Stress on Platelet Function

Effect of Mental Stress on Platelet Function in Healthy Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages

Detailed description

Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases. We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years. The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.

Conditions

• Mental Stress

Interventions

Type	Name	Description
BEHAVIORAL	2-minute Bondet test	2-minute Bondet test

Timeline

• Start date: 2007-09-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2007-10-03
• Last updated: 2010-02-10

Locations

1 site across 1 country: Switzerland