NCT00538044

Simvatstatin Used to Treat Pulmonary Hypertension

the Clinical Research Using Simvastatin as a Medication to Treat Advanced Secondary Pulmonary Hypertension

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: —
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 12 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Detailed description

advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Conditions

• Hypertension, Pulmonary

Interventions

Type	Name	Description
DRUG	simvastatin	medication with simvastation on the dosage of 40mg per day before the operation and all the time after the operation

Timeline

• Start date: 2009-01-01
• Completion: 2012-01-01
• First posted: 2007-10-02
• Last updated: 2007-10-02

Locations

1 site across 1 country: China