NCT00536068

Platelet Inhibition by Aspirin, Acetaminophen and NSAID

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Kantonsspital Graubünden · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.

Detailed description

An in vivo study on healthy volunteers with combinations of well established drugs

Conditions

• Hemostasis

Interventions

Type	Name	Description
DRUG	Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo	1. Acetylsalicylic acid 100mg/po and acetaminophen 3x1g/po for 4 days 2. Acetylsalicylic acid 100mg/po and diclofenac 3x50mg/po for 4 days 3. Acetylsalicylic acid 100mg/po and naproxen 3x250mg/po for 4 days 4. Acetylsalicylic acid 100mg/po and placebo 3x1/po for 4 days

Timeline

• Start date: 2006-08-01
• Completion: 2007-08-01
• First posted: 2007-09-27
• Last updated: 2007-09-28

Locations

1 site across 1 country: Switzerland