NCT00534586

Anesthetics and Auditory, Visceral, and Heat Evoked Potentials

Influence of Anesthetics on Sedation and Antinociception: an Analysis of Auditory Evoked, Visceral Evoked and Heat Evoked Potentials

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.

Detailed description

During surgery patients are exposed to different auditory and sensory stimuli. In this study we investigate the influence of different anesthetics to alertness and nociception. In addition to auditory stimuli (AEP as a measure of sedation), Contact Heat Evoked Potential Stimuli (CHEPS), and esophageal evoked potentials from the lower 1/3 of the esophagus are measured to quantify the effects of anesthetics. 60 Volunteers are enrolled into this study. For each drug, three different levels are measured: * level 1 no medication * level 2 low dose of medication * level 3 light sedation dose (volunteer responds to command) Four drugs are measured in the study: propofol, sevoflurane, S-ketamine and remifentanil.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Propofol	TCI 0.5 mcg/ml 1.0 mcg/ml
DRUG	Remifentanil	continuous infusion 0.05 mcg/kg/min 0.15 mcg/kg/min
DRUG	S-Ketamine	continuous infusion 0.25 mg/kg/h 0.50 mg/kg/h
DRUG	Sevoflurane	via face mask 0.40 Vol% 0.80 Vol%

Timeline

• Start date: 2005-12-01
• Completion: 2007-05-01
• First posted: 2007-09-26
• Last updated: 2007-09-26

Locations

1 site across 1 country: Germany