NCT00533689

Study of the Long-Term Effect of Frequent Anti-VEGF Dosing on Retinal Function in Patients With Neovascular AMD

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 2,008 (estimated)
• Sponsor: Tel-Aviv Sourasky Medical Center · Other Government
• Sex: All
• Age: 50 Years – 90 Years
• Healthy volunteers: —

Summary

THis study aims to determine whether frequent dosing of intravitreal injections of Ranibizumab (Lucentis) or Bevacizumab (Avastin), which act as VEGF inhibitors, has a deleterious effect on the retina, studied by electrophysiologic testing. This prospective, non-randomized clinical study will include patients assigned to intravitreal injection of Ranibizumab or Bevacizumab due to neovascular AMD. The patients will undergo repeat ophthalmic evaluation and intravitreal injections every 4-6 weeks, as long as will be deemed necessary. Periodic electrophysiologic evaluation including Electroretinogram (ERG), electro-oculogram (EOG) and Visual Evoked Potentials (VEP) tests will be performed every 3 months.

Conditions

• Electrophysiology

Interventions

Type	Name	Description
PROCEDURE	Electroretinography (ERG), Visual Evoked Potentials (VEP)

Timeline

• Start date: 2008-01-01
• Completion: 2010-01-01
• First posted: 2007-09-21
• Last updated: 2007-09-21

Locations

1 site across 1 country: Israel