NCT00528788

How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis

Effect of Doxercalciferol on Endothelial Cell Function in End Stage Renal Disease

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Patients with chronic kidney disease and end stage renal disease have greater cardiovascular risk than the general population. Vitamin D analogues have been shown in observational studies to have mortality benefit for these patients. This study is designed to investigate doxercalciferol's effect on the vasculature (i.e. endothelial cell function) as a possible mechanism to explain the mortality benefit.

Conditions

• Hyperparathyroidism, Secondary
• Kidney Failure, Chronic

Interventions

Type	Name	Description
DRUG	doxercalciferol

Timeline

• Start date: 2007-09-01
• Primary completion: 2012-08-01
• Completion: 2012-08-01
• First posted: 2007-09-12
• Last updated: 2016-01-22
• Results posted: 2014-04-14

Locations

1 site across 1 country: United States