NCT00528138

Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation

Prospective Study Comparing Hyperbilirubinemia, CRP, White Blood Cell Count, and Other Clinical Parameters for the Preoperative Diagnosis of Perforated Acute Appendicitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 132 (actual)
• Sponsor: Cirujanos la Serena · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis. The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis. The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.

Detailed description

* Previously validated appendicitis score * Time from onset of symptoms to diagnosis and to surgery * Laboratory values: WBC, CRP, liver function test * SIRS values * Preoperative and postoperative diagnosis * Length of hospital stay * Postoperative complications * Biopsy results

Conditions

• Perforated Appendicitis

Interventions

Type	Name	Description
OTHER	Laboratory Test	CRP, white blood cell count, hepatic function tests

Timeline

• Start date: 2007-10-01
• Primary completion: 2008-09-01
• Completion: 2008-09-01
• First posted: 2007-09-12
• Last updated: 2009-11-10

Locations

1 site across 1 country: Chile