NCT00526344

Bronchoscopy With Bronchial Biopsies Sub-study of: Persistence of Airway Inflammation and Remodeling in Asthma Remission

Bronchoscopy and Bronchial Biopsies. Sub-study of: Characteristics of Asthma Remissions

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 36 (estimated)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims at determining the patterns of asthma remission, the prevalence of these different patterns and the various factors associated with such remissions and possible recurrences of asthma, in order to determine the mechanisms involved in these processes. We therefore want to document these specificities in studying biopsies of subjects in complete remission of their asthma and those in only symptomatic remission of their asthma, in comparison with mildly symptomatic asthmatic subjects and healthy controls.

Detailed description

Primary Outcome Measures : Airway inflammation and remodeling: in bronchial biopsies Secondary Outcome Measures: Comparisons of bronchial biopsy features between groups: * Bronchial epithelial morphology * Bronchial mucosa (smooth muscle, reticular basement membrane, submucosal gland,...)

Conditions

• Asthma

Timeline

• Start date: 2007-09-01
• Completion: 2011-03-01
• First posted: 2007-09-10
• Last updated: 2011-02-14

Locations

1 site across 1 country: Canada